Role of innate immune cells
We are also actively investigating the contribution of different innate immune cells, such as alveolar macrophages, monocytes, neutrophils and dendritic cells in respiratory infection. How these cells alter their properties during and after infection and how this impacts their function and differentiation over time. We are currently investigating the phenomenon of innate immune training, whereby innate cells can retain a "memory" of prior exposure to give an improved anti-bacterial response to subsequent infection. We are utilizing mouse genetics to understand the roles certain genes play in alveolar macrophage development and function.