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Kim, GL, Hooven, TA, Borambuena, JM, Li, B, Boyd, JM, Yang, JH and Parker, D. Growth and stress tolerance comprise independent metabolic strategies critical for Staphylococcus aureus infection. mBio 12(3): e0081421. 2021. PMID: 34101490.


Gonzalez, LA, Mel-Gonzalez, F, Sebastian, VP, Vallejos, OP, Noguera, LP, Suazo, ID, Schultz, BM, Manosalva, AH, Penaloza, HF, Soto, JA, Parker, D, Riedel, CA, Gonzalez, PA, Kalergis, AM, Bueno, SM. Characterization of the Anti-Inflammatory Capacity of IL-10-Producing Neutrophils in Response to Streptococcus pneumoniae Infection. Front Immunol: 12:638917, 2021. PMID: 33995357.


Ha, KP, Clarke, RS, Kim, GL, Brittan, JL, Rowley, JE, Mavridou, DAI, Parker, D, Clarke, TB, Nobbs, AH, Edwards, AM. Staphylococcal DNA Repair is Required for Infection. mBio 11(6): e0228820, 2020. PMID: 33203752.

Peignier, A, Planet, PJ and Parker, D. Differential induction of type I and III interferons by Staphylococcus aureus. Infect Immun, 88(10):e00352-202020. PMID: 32690637.


Ha, KP, Clarke, RS, Kim, GL, Brittan, JL, Rowley, JE, Mavridou, DAI, Parker, D, Clarke, TB, Nobbs, AH and Edwards, AM. Staphylococcal DNA repair is required for infection. mBio 11(6):e02288-20, 2020. PMID: 33203752.

Peignier, A and Parker, D. Impact of type I interferons on susceptibility to bacterial pathogens. Trends in Microbiology. 2021  2:S0966-842X(21)00009-3. PMID: 33546974.


Peignier, A and Parker, D. Pseudomonas aeruginosa can degrade interferon λ, thereby repressing the antiviral response of bronchial epithelial cell. J Interferon Cytokine Res. 40(8): 429-31, 2020. PMID: 32672514.

Peignier, A and Parker, D. Trained immunity and host-pathogen interactions. Cellular Microbiology 22(12): e13261. 2020. PMID: 32902895.


Kim, GL, Akoolo, L and Parker, D. The ClpXP protease contributes to Staphylococcus aureus pneumonia. J Infectious Diseases, 222(8):1400-1404, 2020. PMID: 32386322.

Pires, S, Peignier, A, Seto, J, Smyth, D.S and Parker, D. 2020. Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice. JCI Insight. 5(7): pii: 132223. PMID: 32191638.


Kotenko, S, Rivera, A, Parker, D, and Durbin, J. Type III IFNs: beyond antiviral protection. Seminars in Immunology. 43: 101303. PMID: 31771761.

Jacquet, R, LaBauve, A.E, Akoolo, L, Patel, S, Alqarzaee, A.A, Wong Fuk Long, T, Poorey, K, Stinear, T.P, Thomas, V.C, Meagher, R and Parker, D. Dual gene expression analysis identifies factors associated with Staphylococcus aureus virulence in diabetic mice. Infect Immun, Accepted doi: 10.1128/IAI.00163-19, 2019. PMID: 30833333


Planet, PJ, Parker, D, Ruff, NL and Shinefield HR. Revisiting bacterial interference in the age of methicillin-resistant Staphylococcus aureus: insights into Staphylococcus aureus carriage, pathogenicity and potential control. Pediatr Infect Dis J 38(9):958-966, 2019. PMID: 31274832..

Pires, S and Parker, D. Innate immune responses to Acinetobacter baumannii in the airway. J Interferon Cytokine Res. 39(8):441-449, 2019. PMID: 31013462.

Pires, S and Parker, D. IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms. Eur J Immunol. 48(10): 1707-1716, 2018. PMID: 30051912.


Parker, D.  A live vaccine to Staphylococcus aureus infection. Vaccine. doi: 10.1080/21505594, 2018. PMID: 29402722.


Hook, J.L, Islam, M.N, Parker, D, Prince, A.S, Bhattacharya, S and Bhattacharya, J. Disruption of staphylococcal aggregation protects against lethal lung injury. J Clin Invest. Doi: 10.1172/jci95823, 2018. PMID: 29431734.


Parker, D. CD80/CD86 signaling contributes to the profinflammatory response of Staphylococcus aureus in the airway. Cytokine. pii: S1043-4666(18)30016-4, 2018. PMID: 29402722.


Pires, S, Jacquet, R and Parker, D. Inducible Costimulator contributes to methicillin-resistant Staphylococcus aureus pneumonia. J of Infectious Disease. 218(4): 659-668. PMID: 29378030.


Parker, D. (2017). Humanized mouse models of Staphylococcus aureus infection. Frontiers in Immunology. 8:512. PMID: 28523002.


Wickersham, M, Wachtel, S, Wong Fuk Long, T, Soong, G, Jacquet, R, Richardson, A, Parker, D and Prince, A. (2017). Metabolic stress drives keratinocyte defenses against Staphylococcus aureus infection. Cell Reports. 18(11): 2742-2751. PMID:28297676.


Parker, D. (2016). Impact of type I&III interferons on MDR respiratory superinfections. J Infect Diseases 215(suppl_1): S58-S63. PMID: 28375519.

Ahn, D, Penaloza, H, Wang, Z, Wickersham, M, Parker, D, Patel, P, Koller, A, Chen, E, Bueno, S, Uhlemann, A-C and Prince, A. (2016). Acquired resistance to immune clearance promotes Klebsiella pneumoniae ST258 infection. JCI Insight. 1(17): e89704


Prince, A, Wang, H, Kitur, K and Parker, D. (2016). Humanized mice exhibit increased susceptibility to Staphylococcus aureus pneumonia. J of Infectious Disease. pii: jw425. PMID: 27638942


Kitur, K, Wachtel, S, Brown, A, Wickersham, M, Paulino, F, Penaloza, H.F, Soong, G, Bueno, S, Parker, D and Prince, A. (2016). Cell Reports 16: 1-12


Cohen, T.S, and Parker, D. (2016). Microbial pathogenesis and type III interferons. Cytokine Growth Factor Rev. 29: 45-51. PMID: 26987613.


Parker, D and Prince, A. (2016). Immunoregulatory effects of necroptosis in bacterial infections. Cytokine. 88: 274-5. PMID: 27710879.


Parker, D and Prince, A. (2016). A new approach to toxin neutralization in Staphylococcus aureus therapy. EMBO reports. 17(3):284-5.


Planet, P.J*, Parker, D*, Cohen, T.S*, Smith, H, Leon, J.D, Ryan, C, Hammer, T.J, Fierer, N, Chen, E.I and Prince, A.S. (2016). Interferon-lambda restructures the nasal microbiome and increases susceptibility to Staphylococcus aureus superinfection. mBio 6(2). pii: e00289-15. PMID: 25900653.

*Joint first authors


Parker, D, Ahn, D, Cohen, T and Prince, A. (2016). Innate immune signaling activated by MDR pathogens in the lung. Phys Rev 96: 19-53. PMID: 26582515.


Soong, G, Paulino, F, Wachtel, S, Parker, D, Wickersham, M, Zhang, D, Brown, A, Lauren, C.T, Dowd, M, West, E, Horst, B, Planet, P.J, and Prince, A. (2015). MRSA adaptation to human keratinocytes. mBio 6(2). pii: e00289-15. PMID: 25900653.


Kennan, R.M, Lovett, C, Han, X, Parker, D Turnbull, L, Whitchurch, C.B, and Rood, J. (2015). A two-component regulatory system modulates twitching motility in Dichelobacter nodosus. Veterinary Microbiology pii: S0378-1135(15)00140-6. PMID:26891425.


Kitur, K, Parker, D, Nieto, P, Ahn, D.S, Cohen, T.S, Chung, S, Wachtel, S, Bueno, S, and Prince, A. (2015). Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage. PLoS Pathogens 11(4):e1004820. PMID:25880560.


Amaral, F, Parker, D, Randis, T, Kulkarni, R, Prince, A, Shirasu-Hisa, M and Ranter, A. (2015). Rational manipulation of mRNA folding free energy allows rheostat control of pneumolysin production by Streptococcus pneumoniae. PLoS One. DOI: 10.1371/journal.pone.0119823. PMID: 25798590.


Parker, D, Ryan, C, Alonzo, F, Torres, V, Planet, P and Prince, A. (2014). CD4 T cells contribute to the pathogenesis of MRSA pneumonia. Journal of Infectious Diseases 211(5): 835-45. PMID: 25240171.


Parker, D, LaRussa, S, Ryan, C, Prince, A and Planet, P. (2014). Genome of Staphylococcus aureus strain 502A. Genome announcements 2(2): e00284-14. PMID: 24723721.


Ahn, D.S, Parker, D, Nieto, P, Planet, P and Prince, A. (2014) Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia. Mucosal Immunology 7(6): 1366-1374. PMID: 24736233.


Parker, D, Planet, P, Soong, G and Prince, A. (2014). Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains. PLoS Pathogens. 10(2): e1003951. PMID: 24586160.


Parker, D, Prince A. (2013). Epithelial uptake of flagella initiates proinflammatory signaling. PLoS One. 2013;8(3):e59932. PMID: 23527288.


Parker, D, Prince A. (2012). Staphylococcus aureus Induces Type I IFN Signaling in Dendritic Cells Via TLR9. J Immunol. 2012 Oct 15;189(8):4040-6. PMID:22962685.


Parker, D, and Prince, A. (2012). Immunpathogenesis of Staphylococcus aureus pulmonary infection. Seminars in Immunopathology 34(2): 281-97. PMID:22037948.


Lijek RS, Luque SL, Liu Q, Parker D, Bae T, Weiser JN. (2012). Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase. Proc Natl Acad Sci U S A. 109(34):13823-8. PMID: 22869727.


Soong G, Chun J, Parker D, Prince A. (2012). Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes. J Infect Dis. 2012 May 15;205(10):1571-9. PMID: 22457275.


Parker D, Cohen TS, Alhede M, Harfenist BS, Martin FJ, Prince A. (2012) Induction of Type I Interferon Signaling by Pseudomonas aeruginosa is Diminished in Cystic Fibrosis Epithelial Cells. Am J Respir Cell Mol Biol. 46(1): 6-13. PMID:21778412.


Parker D, Martin FJ, Soong G, Harfenist BS, Aguilar JL, Ratner AJ, Fitzgerald KA, Schindler C, Prince A. (2011). Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract. mBio. May 17;2(3). pii: e00016-11. PMID:21586648.


Parker, D, Prince, A.  (2011). The type I IFN response to extracellular bacteria in the airway epithelium. Trends in Immunology. 2011 32(12):582-8. PMID:21996313 .


Parker D, Prince A. Innate Immunity in the Respiratory Epithelium. (2011). Am J Respir Cell Mol Biol. 45(2):189-201. PMID:21330463.


Naughton S, Parker D, Seemann T, Thomas T, Turnbull L, Rose B, Bye P, Cordwell S, Whitchurch C, Manos J. (2011). Pseudomonas aeruginosa AES-1 Exhibits Increased Virulence Gene Expression during Chronic Infection of Cystic Fibrosis Lung. PLoS One. 2011;6(9):e24526. PMID: 21935417.


Martin FJ, Parker D, Harfenist BS, Soong G, Prince A. (2011) Participation of CD11c+ Leukocytes in Methicillin-Resistant Staphylococcus aureus Clearance from the Lung. Infection and Immunity 79(5):1898-904. PMID:21402768.


Kennan, RM, Wong, W, Dhungyel, O, Han, X, Wong, D, Parker, D, Rosado, CJ. Law, RHP, McGowan, S, Reeve, SB, Levina, V, Powers, GA, Pike, RN, Bottomley, SP, Smith, AI, Marsh I, Whittington, RJ, Whisstock, JC, Porter, CJ and Rood, JI. (2010). Virulence-associated subtilisin-like proteases that utilize a novel disulphide-tethered exosite to mediate substrate specificity. PLoS Pathogens 6(11):e1001210. PMID:21124876.


Parker, D, Soong Soong G, Planet P, Brower J, Ratner AJ, Prince A. (2009). The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation. Infection & Immunity 77(9): 3722-30. PMID:19564377.


Hsiao, Y-S, Parker, D, Ratner, A.J., Prince, A, Tong, L. (2009). Crystal structures of respiratory pathogen neuraminidase. Biochem Biophys Res Commun 380(3):467-71. PMID: 19284989.


Soong G, Parker D, Magargee M, Prince AS. (2008). The type III toxins of Pseudomonas aeruginosa disrupt epithelial barrier function. Journal of Bacteriology 190(8): 2814-21. PMID: 18165298.


Cheetham, B.F., Parker, D., Bloomfield, G.A., Shaw, B.E., Sutherland, M., Hyman, J.A., Druitt, J., Kennan, R.M., Rood, J.I. and Katz, M.E. (2008).  Isolation of the bacteriophage DinoHI from Dichelobacter nodosus and its interactions with other integrated genetic elements.  Open Microbiology Journal. 2:1-9. PMID: 19088904.


Keyburn, A.L, Boyce, J.D, Vaz, P., Bannam, T.L., Ford, M.E, Parker, D, Di Rubbo, A, Rood, J.I, and Moore, R.J. (2008). NetB, a New Toxin is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens. PLoS Pathogens 4(2): e26. PMID: 18266369.


Han X, Kennan RM, Parker D, Davies JK, Rood JI. (2007). Type IV fimbrial biogenesis is required for protease secretion and natural transformation in Dichelobacter nodosus. Journal of Bacteriology 189(14):5022-33. PMID: 17513472.


Parker D*, Myers GS*, Al-Hasani K, Kennan RM, Seemann T, Ren Q, Badger JH, Selengut JD, Deboy RT, Tettelin H, Boyce JD, McCarl VP, Han X, Nelson WC, Madupu R, Mohamoud Y, Holley T, Fedorova N, Khouri H, Bottomley SP, Whittington RJ, Adler B, Songer JG, Rood JI, Paulsen IT. (2007). Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nature Biotechnology 25(5):569-75. PMID:17468768.

*joint first authors


Parker, D., Kennan, R.M., Myers, G.S., Paulsen, I.T., and Rood J.I. (2006) Regulation of type IV fimbriae in Dichelobacter nodosus. Journal of Bacteriology 188(13):4801-11. PMID: 16788189.


Parker, D., Kennan, R.M., Myers, G.S., Paulsen, I.T and Rood, J.I. (2005) Identification of a Dichelobacter nodosus Ferric Uptake Regulator and Determination of Its Regulatory Targets. Journal of Bacteriology 187(1): 366-375. PMID:15601721.

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